Effects of Natural Product-Derived Compounds on Inflammatory Pain via Regulation of Microglial Activation

Inflammatory pain is a type of caused by tissue damage associated with inflammation and characterized hypersensitivity to neuroinflammation in the spinal cord. Neuroinflammation significantly increased various neurotransmitters cytokines that are expressed activated primary afferent neurons, it plays pivotal role development inflammatory pain. The activation microglia elevated levels pro-inflammatory hallmark features neuroinflammation. During neuroinflammation, intracellular signaling pathways or inhibited microglia, leading regulation proteins cytokines. Numerous attempts have been conducted alleviate inhibiting microglial activation. Natural products their compounds gained attention as potential candidates for suppressing due verified safety through centuries use. Many studies also shown natural product-derived suppress Herein, we review literature on mediators involved pain, well found This suggests suppression